pentobarbital will minimize the extent or result of conjugated estrogens by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.

pentobarbital will decrease the level or result of alosetron by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.

Remark: Barbiturates may boost adverse effects, which include respiratory depression, produced by poisonous doses of TCAs. With therapeutic doses of TCAs, barbiturates improve metabolism and decrease blood concentrations of TCAs.

fentanyl transmucosal and pentobarbital the two boost sedation. Stay away from or Use Alternate Drug. Restrict use to sufferers for whom substitute treatment method possibilities are inadequate

pentobarbital will lower the extent or influence of estradiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.

pentobarbital will lower the extent or outcome of apremilast by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Coadministration with strong CYP inducers results in a big lessen of systemic publicity of apremilast, which may cause loss of efficacy

benzhydrocodone/acetaminophen and pentobarbital each boost sedation. Stay clear of or Use Alternate Drug. Restrict use to patients for whom different remedy alternatives are inadequate

pentobarbital will lower the level or influence of methylprednisolone by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.

In case the buprenorphine dose is insufficient as well as the CYP3A4 inducer can't be lowered or discontinued, changeover the affected individual back to the buprenorphine formulation that allows dose changes.

pentobarbital will decrease the level or effect of cevimeline get more info by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Importance Unknown.

pentobarbital will lower the level or outcome of alfentanil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Significance Unknown.

pentobarbital will lower the level or result of tramadol by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe. Lessened AUC of tramadol and the Lively metabolite (O-desmethyltramadol) when coadministered with potent CYP3A4 and CYP2B6 inducers

pentobarbital will reduce the extent or result of fedratinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Outcome of coadministering a powerful CYP3A4 inducer with fedratinib hasn't been researched.

pentobarbital will reduce the extent or impact of doxorubicin by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.